March 13, 2022
Atlanta United (vs Charlotte FC)
March 20, 2022
Austin FC (vs Seattle Sounders)
April 2, 2022
San Jose Earthquakes (vs Austin FC)
April 9, 2022
LA Galaxy (vs LAFC)
April 17, 2022
LAFC (vs Sporting KC)
April 23, 2022
Austin FC (vs Vancouver Whitecaps FC)
May 7, 2022
Charlotte FC (vs Inter Miami)
May 15, 2022
Atlanta United (vs New England Revolution)
May 22, 2022
Inter Miami (vs New York Red Bulls)
May 28, 2022
Orlando City SC (vs FC Dallas)
June 18, 2022
Seattle Sounders (vs LAFC)
June 25, 2022
San Jose Earthquakes (vs LA Galaxy)
June 29, 2022
Seattle Sounders (vs CF Montreal)
July 8, 2022
LAFC (vs LA Galaxy)
July 13, 2022
LA Galaxy (vs San Jose Earthquakes)
July 23, 2022
Orlando City SC (vs Philadelphia Union)
July 30, 2022
Minnesota United FC (vs Portland Timbers)
August 6, 2022
Atlanta United (vs Seattle Sounders)
August 10, 2022
MLS ALL STAR - St. Paul, MN
August 13, 2022
FC Cincinnati (vs Atlanta United)
August 21, 2022
Nashville SC (vs FC Dallas)
August 27, 2022
FC Cincinnati (vs Columbus Crew)
August 31, 2022
New England Revolution (vs Chicago Fire)
September 4, 2022
Inter Miami FC (vs Orlando City SC)
September 10, 2022
Nashville SC (vs Philadelphia Union)
September 13, 2022
Minnesota United FC (vs LAFC)
September 17, 2022
Chicago Fire FC (vs Charlotte FC)
October 1, 2022
Charlotte FC (vs Philadelphia Union)
October 9, 2022
Orlando City SC (vs Columbus Crew)